Metyrapone / Ketoconazole day series

Why am I having this test?

Your doctor has referred you to have Metyrapone / Ketoconazole day series to check that your medication dose is appropriate.

Do I need to prepare for the test?

You will receive a separate appointment letter which will inform you if you need to fast for any of the other bloods being taken at this visit. You should take your usual dose of Ketaconazole or Metyrapone at your usual times as well as your other medications. Please tell the nurse what time you have taken them.

Please bring all your medications you will need to take during the day with you.

What happens during the test?

A fine plastic tube called a cannula will be inserted into a vein in your arm, to allow us to take blood samples at regular intervals. Routine blood samples will be taken then the cannula will be flushed with saline and following each blood sampling. Between these times you are free to leave the unit if you wish.

How long will the test take?

The test lasts from 09:00 to 17:00 with sampling for cortisol at two hourly intervals. Between these times you may be able to leave the unit but not the hospital, as you will have the cannula in situ. When the test is completed the cannula will be removed and you will be able to go home.

Will I experience any side effects?

The test has no common side effects.

When will I get my results?

Your results will be reviewed by your endocrine doctor and you and your GP will be notified if any changes to your treatment are required. It may be necessary to contact you by telephone, so it is helpful if you could give us your home and mobile telephone numbers when you come in for your test.

Any other questions?

Please contact the Endocrine Unit on 01223 217848.

The timing of the test is important so please attend at the time specified on your appointment letter. If you are unable to attend your appointment please contact the endocrine unit to re-arrange it.

General information

Discounted parking is available for patients attending clinic appointments over three hours’ duration. Please present your appointment letter to receive this.

Food & drink – there is a coffee shop in the treatment centre atrium and further food and drink facilities in the main hospital concourse.