Angiotensin II inhibitors

Examples

The following are some examples of brand names of Angiotensin II inhibitors:

• Candesartan
• Olmesartan
• Losartan
• Valsartan
• Irbesartan

What are angiotensin II inhibitors and what do they do?

Angiotensin II inhibitors are used to help to control high blood pressure (also known as hypertension).

The kidneys have a major influence on blood pressure and it is particularly important to monitor blood pressure in patients who have kidney disease. There are three reasons for this:

• Many kidney diseases cause high blood pressure – high blood pressure is very common in people with kidney diseases or failing kidneys.
• High blood pressure can cause further damage to diseased kidneys.
• People with kidney disease and failure are at high risk of developing heart disease and circulation problems.

Why am I prescribed an angiotensin II inhibitor?

An angiotensin II inhibitor has been prescribed for you to help to control your blood pressure and to help prevent further damage to your kidneys which may be caused by high blood pressure.

If you have had ACE inhibitors in the past and have had side effects, you may have been prescribed an angiotensin II inhibitor (such as lisinopril, Ramipril or Perindopril) as an alternative. For some patients an angiotensin II inhibitor may be prescribed in addition to an ACE inhibitor.

How do I take my angiotensin II inhibitor?

Most angiotensin II inhibitors are taken once daily and can be taken regularly at any time of the day. If you feel dizzy or light headed after taking a dose, it may be best to take your angiotensin II inhibitor before going to bed.

Do I need to have any tests or be monitored because I am taking an angiotensin II inhibitor?

You will need to have your blood pressure monitored frequently by your doctor.

Your doctor will alter the dose(s) of your high blood pressure medicines if your blood pressure is too high or too low.

Your doctor will also monitor your potassium level and kidney function closely as these can be affected by angiotensin II inhibitors. It is important that your potassium level and renal function are checked by your GP one week after starting to take these tablets – make sure that you make an appointment at your surgery for a blood test to be done.

Are there any side effects?

The main adverse effects seen with angiotensin II inhibitors include:

• An upset stomach
• Indigestion
• Diarrhoea or constipation

These side effects should be mild but if you have any concerns about these or any other side effects please contact your doctor or specialist nurse for advice.

Are there any problems taking angiotensin II with any other medications?

You should avoid any medicine which contains a high level of potassium whilst you are taking an angiotensin II inhibitor. Such medicines include many indigestion remedies (such as Gaviscon® Advanced) and remedies for cystitis (such as Effercitrate®) that you can buy at all pharmacies and many supermarkets and garages.

Only take tablets prescribed for you by your doctor and check with your pharmacist before taking any new medicines.

Further information

Further information about your tablet can be found in the patient information leaflet found in the tablet/capsule box or on the container.

If you have any other questions about your medication, please contact the medicines helpline on 01223 217502.